997 ACUTE AND LATE GASTROINTESTINAL BLEEDING EVENTS AFTER LEFT VENTRICULAR MECHANICAL SUPPORT IMPLANTATION: THE ISMETT REGISTRY

Abstract Background The number of patients with end stage heart failure (HF) which requires a ventricular assist devices (VADs) implantation is constantly increasing. Gastrointestinal bleeding (GIB) represents one the most common complications that occur in this patient population. GIB risk assessment could have important implications for candidate selection and postimplant therapeutic strategies. A recent model, called UTAH score (UBRS), was created aim predicting during LVAD support, but its use does not yet worldwide validation. two popular (BR) scores available, ARC-HBR HAS-BLED scores, been validated respectively setting percutaneous coronary intervention atrial fibrillation their VAD limited. Aims to describe clinical outcome gastrointestinal underwent at single tertiary referral hospital transplant. Furthermore, explore possible correlation among clinical, echocardiographic, hemodynamic parameters development has evaluated. Finally, evaluate predictive value UBRS, population propose new capable patients. Methods Between November 2010 December 2021, 75 consecutive who enrolled monocentric retrospective registry. Univariable multivariable Cox regression analysis were performed identify factors independently associated GI study Results Patient's mean age 57,8 ± 8,8 years. Thirty-six (48%) died time 579 481 days after implant VAD. overall survival 66,6% To follow-up 737 593 days, total 44 (incidence 58,7%) occurred 30 Nineteen (25%) experienced 21 events. Mean first 469 520 only event within days.The years did differ significantly between those (58% vs 69,6%; p=0,3). While, considering bleedings, mortality higher developed any event, than bleed (67 35%; p= 0,008).The characteristics without similar regard age, INTERMACS profile, etiology indication.The subgroup demonstrated low cardiac output (P< 0,001), right disfunction (P=0,01) severe mitral regurgitation (P= 0,01) all increased GIB. In our population, high profile UBRS shown be related percentage GIB, compared prevailed (p< 0,001). Instead, didn't prove effective Conclusions High rates do impact negatively survival. Total bleedings are correlated mortality. Reduced output, independent factors. able stratify risk, order predict tested, while not.